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Filtered Search Results
Medchemexpress LLC 9(10H)-acridinone, 10-(3-aminopropyl)-3,4-dimethyl-, (2Z)-2-butenedioate (1:1) | 1204480-26-1 | 99.4% | 396.44 | 25 MG
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ER-27319 (maleate), an acridone derivative, is a potent and selective SYK inhibitor. It inhibits the tyrosine phosphorylation of SYK and its activity. This compound also inhibits the release of antigen-induced allergic mediators from human and rat mast cells with an IC50 of 10 μM, making it useful for studying allergic diseases.
- Potent and selective SYK inhibitor.
- Inhibits tyrosine phosphorylation of SYK and its activity.
- Inhibits the release of antigen-induced allergic mediators from human and rat mast cells with an IC50 of 10 μM.
- Useful for study in allergic diseases.
- Available in solid form, yellow to orange color.
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Medchemexpress LLC U-99194 maleate | 234757-41-6 | 99.2% | 10 MG
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U-99194 maleate is a selective, potent dopamine D3 receptor antagonist with a Ki of 160 nM. It inhibits the activation of the D3 receptor mediated by endogenously released dopamine or exogenous D3 agonists. This compound can be used for the study of dopamine D3 receptor-mediated motor disorders, particularly kinetic tremors.
- Selective, potent dopamine D3 receptor antagonist
- Inhibits activation of D3 receptor
- Abrogates IPSC-suppressive effect of D3 agonist PD 128907 in rat hippocampal slices
- Significantly suppresses nicotine-induced tremor in mice
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eMolecules 4-(3-Dimethylamino-propoxy)-phenylamine dihydrochloride | 1150658-32-4 | MFCD12026492 | 5g
J & W PharmLab, LLC | 4-(3-Dimethylamino-propoxy)-phenylamine dihydrochloride | 5g | 249976256 | 20R0861S | 97.000 | 1150658-32-4 | MFCD12026492 | 267.190 | C11H20Cl2N2O
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Medchemexpress LLC ST-148 maleate | 390803-40-4 | 99.4% | 612.74 | 1 MG
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ST-148 maleate is a potent and orally active DENV inhibitor. It demonstrates antiviral efficacy and low cell toxicity. ST-148 maleate works by altering the interaction between lipid droplets and the C protein, which in turn inhibits viral replication.
- Potent and orally active DENV inhibitor
- Demonstrates antiviral efficacy
- Low cell toxicity
- Inhibits viral replication
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Medchemexpress LLC Neratinib maleate | 915942-22-2 | 99.7% | 673.11 | 100 MG
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Neratinib maleate is an orally available, irreversible, highly selective HER2 and EGFR inhibitor with IC50s of 59 nM and 92 nM, respectively. It is for research use only.
- Orally available
- Irreversible inhibitor
- Highly selective HER2 and EGFR inhibitor
- Inhibits proliferation of cell lines with high HER-2 levels
- Less active in cell lines expressing neither HER-2 nor EGFR
- Arrests BT474 cell cycle at G1-S phase
- Inhibits MAPK and Akt phosphorylation
- Down-regulates cyclin D1 levels
- Induces p27
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Medchemexpress LLC Mepyramine maleate (pyrilamine maleate) | 59-33-6 | 99.9% | 1 ML
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Mepyramine maleate is a first-generation antihistamine that acts as an antagonist of the histamine H1 receptor. It is characterized by specific binding affinities for H1, H2, and H3 receptors.
- Antagonist of the histamine H1 receptor
- Binds to H1 receptor with Kd of 0.8 nM
- Exhibits Kds of 5200 nM for H2 and >3000 nM for H3 receptors
- Decreases InsP levels in CHO-gpH1 cells
- Reduces maximal response to ATP in CHO-gpH1 cells
- Demonstrates analgesic effects in vivo at specific dosages
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eMolecules AstaTech / BIACETYL / 5g / 718060638 / W18292 / 95.000 / 431-03-8 / MFCD00008756 / 86.090 / C4H6O2
AstaTech / BIACETYL / 5g / 718060638 / W18292 / 95.000 / 431-03-8 / MFCD00008756 / 86.090 / C4H6O2
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Chemscene CHEMSCENE
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5000579338 DIETHYL MALEATE 1KG
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Medchemexpress LLC Tegaserod (maleate) | 189188-57-6 | 99.9% | C20H27N5O5 | 25 MG
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Tegaserod maleate is an orally active serotonin receptor 4 (HTR4; 5-HT4R) agonist and a 5-HT2B receptor antagonist. It induces tumor cell apoptosis, blunts PI3K/Akt/mTOR signaling, and decreases S6 phosphorylation, exhibiting anti-tumor activity.
- Orally active serotonin receptor 4 (HTR4; 5-HT4R) agonist
- 5-HT2B receptor antagonist
- Induces tumor cell apoptosis
- Blunts PI3K/Akt/mTOR signaling
- Decreases S6 phosphorylation
- Exhibits anti-tumor activity
- Potential for irritable bowel syndrome (IBS) research
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Medchemexpress LLC Decursinol angelate | 130848-06-5 | 5 MG
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Decursinol angelate acts as a PKC activator and GDH inhibitor, with an IC50 of 1.432 μM against human GDH. It activates PKC, downregulates PKCα and PKCβII isoforms, and exhibits cytotoxic activity against cancer cells. Decursinol angelate also inhibits VEGF-induced autophosphorylation of VEGFR2, downstream p42/44 ERK and JNK-MAPK signaling pathways, and the angiogenesis process. It is applicable to research related to cancer and leukemia.
- Potent PKC activator
- Inhibits human glutamate dehydrogenase (IC50 1.432 μM)
- Exhibits cytotoxic activity against various human cancer cell lines
- Inhibits VEGF-induced angiogenesis
- Modulates macrophage polarization through NFκB and MAPK pathways
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Sigma Aldrich Fine Chemicals Biosciences Methyl acetate anhydrous, 99.5% | 79-20-9 | MFCD00008711 | 1L
Methyl acetate anhydrous, 99.5% | Purity: 99.5% | Mol Wt: 74.08 | 79-20-9 | MFCD00008711 | 1L
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eMolecules 4-Amino-cyclohexanecarboxylic acid ethyl ester hydrochloride | 90950-09-7 | MFCD12913688 | 5g
J & W PharmLab LLC | 4-Amino-cyclohexanecarboxylic acid ethyl ester hydrochloride | 5g | 289350796 | 20R0641S | 96.000 | 90950-09-7 | MFCD12913688 | 207.700 | C9H18ClNO2
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Medchemexpress LLC Asenapine maleate | 85650-56-2 | 99.95% | 401.84 | 10 MG
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Asenapine maleate (Org 5222 maleate) is a brain-penetrant atypical antipsychotic, serving as an antagonist for serotonin receptors (pKi: 8.4-10.5), adrenoceptors (pKi: 8.9-9.5), dopamine receptors (pKi: 8.9-9.4), and histamine receptors (pKi: 8.2-9.0). This compound is valuable in the research of schizophrenia and bipolar disorder.
- Higher affinity for 5-HT2C, 5-HT2A, 5-HT2B, 5-HT7, 5-HT6, α2B, and D3 receptors compared to D2 receptor affinity.
- Demonstrated anxiolytic-like effects in animal models.
- Used for treating schizophrenia and bipolar I disorder.
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Medchemexpress LLC Monomethylauristatin F hydrochloride | 1415246-68-2 | 768.42 | C39H66ClN5O8 | 50 MG
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MMAF hydrochloride (Monomethylauristatin F hydrochloride) is a potent tubulin polymerization inhibitor used as an antitumor agent and as the cytotoxic payload in antibody-drug conjugates (ADCs). It is supplied in small milligram-scale amounts for research and ADC development.
- Potent tubulin polymerization inhibitor.
- Used as a cytotoxic component in ADCs.
- CAS number 1415246-68-2.
- Molecular weight 768.42.
- Chemical formula C39H66ClN5O8.
- Supplied as a solid in milligram quantities for research use.
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Medchemexpress LLC Asenapine maleate | 85650-56-2 | 99.95% | 401.84 | 50 MG
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Asenapine maleate, a brain-penetrant atypical antipsychotic, acts as an antagonist of serotonin receptors, adrenoceptors, dopamine receptors, and histamine receptors. It is used in the research of schizophrenia and bipolar disorder.
- Exhibits high affinity for several serotonin, adrenergic, and dopamine receptors, indicating strong target engagement.
- Acts as a potent antagonist at various serotonin, dopamine, adrenergic, and histamine receptors.
- Demonstrates potential for superior therapeutic effect on anxiety symptoms in animal models.
- Shows anxiolytic-like effects in behavioral tests in mice.
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